Best Age to Conceive a Child

बच्चा पैदा करने की सबसे अच्छी उम्र... 


Former Director Grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad, India 

As said Age is the number only but it is not very true in terms of bearing a child.

Child bearing age is well defined. In Ayurveda, it is said that you may be healthy centenarian but you lose progressively efficiency of certain organs every decade of your life. All cells experience changes with Physiological aging and precede towards senescence. They become larger and are less able to divide and multiply. Many cells lose their ability to function, or they begin to function abnormally. As aging continues, waste products build up in tissue and of the ability to adapt to metabolic stress. Aging begins as soon as adulthood is reached and is as much a part of human life as are infancy, childhood, and adolescence. After attaining youth one loses acivity of thymus and you stop growing in height.

 The cardiac output decreases, blood pressure increases and arteriosclerosis develops. The lungs show impaired gas exchange, a decrease in vital capacity and slower expiratory flow rates. All these affect physiology and sociology of reproduction. 

Technically, women can get pregnant and bear children from puberty when they start getting their menstrual period to menopause, they can lead healthy life but cannot bear child . The average woman’s reproductive years are between ages 12 and 51. The age-related fertility decline is an inevitable part of being a woman .Her ability to have children depends on whether her ovaries have enough good eggs that can progress into a healthy pregnancy. However, eggs, like other body cells, degrade over time, causing a decline in fertility rates by age. For women in their 20s, these natural processes are barely noticeable; in fact, 96% of women below 25 succeed in getting pregnant within a year. Those in their 30s start noticing first signs of fertility limitations, but still have a good chance of conceiving. Entering 40, however, creates many reproductive challenges as it becomes almost impossible for women to get pregnant naturally. Understanding the relationship between fertility and age is, therefore, necessary for proper family planning and to have healthy society. 

Fig.1. Condition of the ovary in the different age groups

Fertility and Age: Because age is the most important factor affecting fertility, understanding how exactly it affects a woman’s chances of conceiving is important to make the most out of her reproductive years. A woman’s fertility mainly depends on her ovarian reserve, which is the capacity of her ovaries to provide viable eggs that can be released on ovulation (Fig.1) , fertilized by sperm, and develop into a healthy pregnancy. However, like all other cells in the body, women’s eggs age, resulting in a natural decline in their count and quality. Women are born with a lifetime supply of eggs, and the body cannot produce more throughout their life. The decline of female egg count by age occurs in the following pattern through various life stages:

•At birth, ovaries contain between 1-2 million egg cells, which will degrade until puberty. 

• At puberty, girls have about 350,000-500,000 eggs in the ovaries.

• Mensuration. From puberty until menopause, up to about 1,000 eggs will be recruited to be matured during each menstrual cycle, in which one egg will be released on ovulation. 

• At menopause, the ovarian reserve is down to zero, and women no longer ovulate nor conceive.

Egg quality refers to the potential of the eggs to be fertilized, implanted, and developed into a healthy fetus, which is determined by their DNA composition. Over time, there are chromosomal (DNA) changes in the eggs due to sicknesses, fevers, toxins, and other factors. An egg with such abnormalities is not viable and will cause a series of complications if it is released on ovulation day, including not being fertilized, failing to implant in the uterine wall, or leading to a miscarriage or birth defects in the foetus. Because egg quality cannot be improved, abnormal eggs accumulate over time ,resulting in a higher percentage of abnormal eggs among older women, as shown in this egg quality. 

Age chart:

• Usually before 30, women have mostly normal eggs with a few abnormal ones

• Between 30 and 40, the percentage of abnormal eggs starts to increase while normal egg counts decrease.

• After 40, women have mostly abnormal with very few normal ones.

Fertility Rates by Age:

Now that we understand what factors play a role in a woman’s fertility, let’s put that into perspective and take a look at fertility rates by the odds of getting pregnant can be affected by other factors, such as medical conditions, ovulation problems, or partner’s sperm quality. 

Fertility Rates in 20s•

Women in their 20s enjoy the highest fertility, with 24 typically being quoted as the peak fertility age

.• Their egg pool is abundant, and most of their eggs do not have chromosomal abnormalities, both of which guarantee heightened likelihood of conception.

• Before the age of 30, women have a 25% chance of getting pregnant in a given menstrual cycle

.• About 96% of those younger than 25 and 86% of those approaching 30 will get pregnant within a year of trying

.• Miscarriage rates are low, around 10%

Fertility Rates in 30s:

Turning 30 is when many women start being aware of possible fertility limitations.

Although late 30s come with some new challenges, generally pregnancy in this age range is still very much possible for most women.

 Early 30s

• Chances of getting pregnant for women younger than 35 are still high.

• Every month, there is a 20% chance of conceiving for women in that age group.

• Over a 12 month period, it is estimatedthat 86% of women 30 to 34 years old will get pregnant.

 Mid to late 30s

• Going into mid- and late-30s, women’s odds of conceiving are lower, but still good. There are some important considerations to take into account.

• Fertility at 35 might become an issue as the decline in ovarian reserve begins to accelerate at faster rates. This means that although egg count is still relatively high, there are more DNA abnormalities that can complicate egg fertilization and its progression into pregnancy.

• At this age, a woman’s chances to get pregnant within a given cycle drop to 15%.

• The risk of miscarriage increases to 20-25%.The risk of genetic conditions, such as Down syndrome, increases as well. (For comparison,  at 25, there is a 1 in 1,200 risk.At 35, it increases to 1 in 350 pregnancies.)

• However, 78% of women in their mid- and late30s conceive within a year and go on to have healthy pregnancies.

• Mid-30s is also the time when doctors begin talking about infertility. Generally, women younger than 35 are advised to seek help after they failed to conceive after a year of trying.

This recommendation shortens to six months for women past 35.Fertility Rates in 40sFertility at 40 takes on a steeper decline. It is not only more difficult for women to get pregnant, but also stay pregnant and have a healthy pregnancy. In fact, studies have shown that in the 40s, fertility declines by roughly 10% every two years. 

Fertility Rates in Early 40s

• Anatural conception is harder, and it might take longer. However, it is still possible for women after 40.

• Women in this age range have a 5% chance of getting pregnant naturally every cycle

.• Their odds of pregnancy within a year are 40%,less than half of what it was in their 20s.

• Miscarriage rates are significantly higher, too, about 34%.• More women have to rely on assisted reproductive technologies (ARTs), such as IVF, to achieve pregnancy. 

Mid 40s

• Women in their mid-40s typically enter the menopausal transition, during which they  might have irregular periods and ovulation problems, making it virtually impossible to conceive naturally.

• The ovaries contain a very low number of eggs, and most of them have chromosomalabnormalities. Even is fertilization does occur, there is a high risk of pregnancyloss and genetic abnormalities.

•At this age, the odds of getting pregnant within a year are only 1-3%.

• Most pregnancies are achieved with the help of donor eggs and assisted reproductive technology.

• Miscarriage rates increase to 53%, and the risk of Down syndrome is very high, 1 in 10pregnancies.Health conditions that may complicate pregnancy complications. 

One-third of reproductive age women have health conditions that may complicate pregnancy.  “The prevalence of chronic health conditions among reproductive-age women is surprising because we think of them as being one of our healthiest populations,” says Lori Gawron.

Unfortunately, many of these women aren’t seeing an OB/GYN until they are pregnant. There are 10 common pre-existing conditions that can cause expectant mothers problems during pregnancy (Fig.2) 

Fig.2. One in three women of reproductive age have at least one chronic condition that could compromise their health or lead to adverse outcomes during pregnancy, according to a new study conducted by University of Utah Health scientists.   

Among the women at risk for complications during pregnancy are those who have a history of heart disease, breast cancer, epilepsy, high blood pressure, and diabetes. “It is completely up to the woman with a chronic condition and her family to determine if she wants to become pregnant,” Gawron says. “But I want her to understand what the risks are aheadof time. If she isn’t willing to take those risks, then she should be using the safest and most effective birth control method that works for her.” (The author has his own study and views)